Glycolysis Made Easy

YouTube Video 2- Glycolysis

This video on glycolysis is very concise and appealing to the eyes. The video makes use of a step by step diagram which is easy to follow. The notes are short and to the point. According to the video glucose is converted to glucose-6-phosphate by adding a phosphate group from ATP in the presence of hexokinase. Glucose-6-phosphate is converted to fructose-6-phosphate by phospoglucose isomerase which is then converted to fructose-1,6-bisphosphate by adding a phosphate group from ATP in the presence of phosphofructokinase. The fructose-1,6-bisphosphate is converted to 2 triose phosphate isomers, dihydroxyacetone Phosphate and glyceraldehyde-3-phosphate, by the enzyme aldose. The enzyme triose phosphate isomerase regulates these isomers by favouring one over the other depending on the concentration of ATP and ADP. When the body requires ATP glceraldehyde-3-phosphate is favoured and is converted to two 1,3-bisphosphoglycerate by the removal of H+ and addition of a phosphate group from NAD+P in the presence of glyceraldehyde phosphate dehydrogenase. 2 ATP is produced by removing a phosphate group in the presence of phosphoglycerate kinase to produce two 3-phosphoglycerate. These are converted to 2-phosphoglycerate by phosphoglyceromutase. Enolase is used to remove 2 water molecules to produce two phosphoenolpyruvate. Finally pyruvate kinase converts the phosphoenolpyruvate to 2 pyruvate by removing a phosphate group per compound to produce 2 ATP. Therefore in total 4 ATP is produced per glucose, 2 ATP is used per glucose, 2 pyruvates is produced per glucose, 2 NADH+H is produced per glucose and 2 water molecules is produced per glucose.